Benefits of Chamomile in Fine's Sleep Aid Gummies

Benefits of Chamomile in Fine's Sleep Aid Gummies

Chamomile includes a range of different daisy-like plants, which belong to the Asteraceae family. Different species of chamomile exist including German chamomile (Marticaria recutita) and Roman chamomile (Chamaemelum nobile). These two species have been used since Ancient times for their calming and anti-inflammatory properties and each may offer other additional health benefits.

Chemical Composition

  • Sesquiterpenes
  • Flavonoids
  • Chlorogenic acid
  • Caffeic acid
  • Apigenin
  • Apigenin-7-O-glucoside
  • Luteolin
  • Luteolin-7-O-glucoside
  • Quercetin
  • Rutin
  • Naringenin
  • Coumarins
  • Herniarin
  • Umbelliferone
  • (Z)- and (E)-2-β-d-glucopyranosyloxy-4-methoxycinnamic acid (GMCA)
  • Polyacetylenes

Possible Health Benefits

  • 1. Improves Quality of Sleep
  • A recent clinical trial (2017) entitled “The effects of chamomile extract on sleep quality among elderly people: A clinical trial” published in “Complementary Therapies in Medicine” concluded “

    The use of chamomile extract can significantly improve sleep quality among elderly people. Thus, it can be used as a safe modality for promoting elderly people's sleep”.

    A recent clinical trial (2016) entitled “Effects of an intervention with drinking chamomile tea on sleep quality and depression in sleep disturbed postnatal women: a randomized controlled trial” published in the Journal of Advanced Nursing concluded “Chamomile tea may be recommended to postpartum women as a supplementary approach to alleviating depression and sleep quality problems”.

  • 2. Improves Anxiety

  • A recent clinical trial (2016) entitled “Long-term chamomile (Matricaria chamomilla L.) treatment for generalized anxiety disorder: A randomized clinical trial” published in Phytomedicine : International Journal of Phytotherapy and Phytopharmacology concluded “Long-term chamomile was safe and significantly reduced moderate-to-severe GAD symptoms, but did not significantly reduce rate of relapse. Our limited sample size and lower than expected rate of placebo group relapse likely contributed to the non-significant primary outcome finding. Possible chamomile superiority over placebo requires further examination in large-scale studies”.

    A research study (2009) entitled “A randomized, double-blind, placebo-controlled trial of oral Matricaria recutita (chamomile) extract therapy for generalized anxiety disorder” published in the Journal of Clinical Psychopharmacology concluded “This is the first controlled clinical trial of chamomile extract for GAD. The results suggest that chamomile may have modest anxiolytic activity in patients with mild to moderate GAD. Future studies are needed to replicate these observations”.

    3. Improves Depression

    A clinical study (2012) entitled “Chamomile (Matricaria recutita) May Have Antidepressant Activity in Anxious Depressed Humans - An Exploratory Study” published in Alternative therapies in health and medicine concluded “Chamomile may have clinically meaningful antidepressant activity that occurs in addition to its previously observed anxiolytic activity”.

    4. Prevents Damage of Free Radicals

    A recent research study (2016) entitled “Chamomile decoction extract inhibits human neutrophils ROS production and attenuates alcohol-induced haematological parameters changes and erythrocytes oxidative stress in rat” published in Lipids in Health and Disease concluded “These findings suggest that CDE inhibits neutrophil ROS production and protects against EtOH-induced haematologiacal parameters changes and erythrocytes oxidative stress. The haematoprotection offered by chamomile might involve in part its antioxidant properties as well as its opposite effect on some intracellular mediators such as H2O2, free iron, and calcium”.

    5. Improves Inflammation

    A research study (2010) entitled “Chamomile, an anti-inflammatory agent inhibits inducible nitric oxide synthase expression by blocking RelA/p65 activity” published in the International Journal of Molecular Medicine concluded “These results demonstrate that chamomile inhibits NO production and iNOS gene expression by inhibiting RelA/p65 activation and supports the utilization of chamomile as an effective anti-inflammatory agent”.

    A research study (2009) entitled “Chamomile, a novel and selective COX-2 inhibitor with anti-inflammatory activity” published in Life Sciences concluded “Our data suggest that chamomile works by a mechanism of action similar to that attributed to non-steroidal anti-inflammatory drugs”.

    6. Protects Liver

    A recent study (2015) entitled “Chemical composition, antioxidant properties and hepatoprotective effects of chamomile (Matricaria recutita L.) decoction extract against alcohol-induced oxidative stress in rat” published in General Physiology and Biophysics concluded “In conclusion, our data suggest that CDE exerted a potential hepatoprotective effect against EtOH-induced oxidative stress in rat, at least in part, by negatively regulating Fenton reaction components such as H(2)O(2) and free iron, which are known to lead to cytotoxicity mediated by intracellular calcium deregulation”.

    7. Improves Diabetes

    A research study (2014) entitled “Chamomile tea: herbal hypoglycemic alternative for conventional medicine” published in Pakistan Journal of Pharmaceutical Sciences concluded “Results from the present study indicate that chamomile tea have a glucose lowering effect in diabetic rats so its daily consumption can be potentially useful in hyperglycemia and it can be used as a substitute of conventional drug treatment. Further studies are necessary to elucidate the exact molecular mechanism involved in anti-diabetic action of chamomile”.

    A clinical study (2015) entitled “Effectiveness of chamomile tea on glycemic control and serum lipid profile in patients with type 2 diabetes” published in the Journal of Endocrinological Investigation concluded “Chamomile tea has some beneficial effects on glycemic control and serum lipid profile in T2DM patients”.

    A research study (2013) entitled “Antidiabetic Effects of Chamomile Flowers Extract in Obese Mice through Transcriptional Stimulation of Nutrient Sensors of the Peroxisome Proliferator-Activated Receptor (PPAR) Family” published in PloS One summarized:

    • Given the significant increases in the incidence of metabolic diseases, efficient strategies for preventing and treating of these common disorders are urgently needed.

    • This includes the development of phytopharmaceutical products or functional foods to prevent or cure metabolic diseases.

    • Plant extracts from edible biomaterial provide a potential resource of structurally diverse molecules that can synergistically interfere with complex disorders.

    • In this study we describe the safe application of ethanolic chamomile (Matricaria recutita) flowers extract (CFE) for the treatment and prevention of type 2 diabetes and associated disorders.

    • We show in vitro that this extract activates in particular nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ) and its isotypes.

    • In a cellular context, in human primary adipocytes CFE administration (300 µg/ml) led to specific expression of target genes of PPARγ, whereas in human hepatocytes CFE-induced we detected expression changes of genes that were regulated by PPARα.

    • In vivo treatment of insulin-resistant high-fat diet (HFD)-fed C57BL/6 mice with CFE (200 mg/kg/d) for 6 weeks considerably reduced insulin resistance, glucose intolerance, plasma triacylglycerol, non-esterified fatty acids (NEFA) and LDL/VLDL cholesterol.

    • Co-feeding of lean C57BL/6 mice a HFD with 200 mg/kg/d CFE for 20 weeks showed effective prevention of fatty liver formation and hepatic inflammation, indicating additionally hepatoprotective effects of the extract.

    • Moreover, CFE treatment did not reveal side effects, which have otherwise been associated with strong synthetic PPAR-targeting molecules, such as weight gain, liver disorders, hemodilution or bone cell turnover.

    • Taken together, modulation of PPARs and other factors by chamomile flowers extract has the potential to prevent or treat type 2 diabetes and related disorders.

    • As demonstrated here, the application of plant-derived extracts as selective gene expression activators highlights the unique biological properties of natural resources to counteract metabolic diseases, and suggests that tailored dietary intervention may represent a fruitful approach for alleviating common diseases.

    8. Improves Diarrhea

    A research study (2014) entitled “Antidiarrheal and antioxidant activities of chamomile (Matricaria recutita L.) decoction extract in rats” published in the Journal of Ethnopharmacology concluded “These findings suggested that chamomile extract had a potent antidiarrheal and antioxidant properties in rats confirming their use in traditional medicine”.

    9. Improves PMS Symptoms

    A clinical study (2014) entitled “Comparison of the effects of Matricaria chamomila (Chamomile) extract and mefenamic acid on the intensity of premenstrual syndrome” published in Complementary therapies in clinical practice concluded “ Consumption of Chamomile seems to be more effective than MA in relieving the intensity of PMS associated symptomatic psychological pains”.

    10. Other Health Benefits

    A review article (2011) entitled “Chamomile: A herbal medicine of the past with bright future” published in Molecular Medicine Reports concluded:

    • Chamomile has been used as an herbal medication since ancient times, is still popular today and probably will continue to be used in the future because it contains various bioactive phytochemicals that could provide therapeutic effects.

    • Chamomile can help in improving cardiovascular conditions, stimulate immune system and provide some protection against cancer.

    • Establishing whether or not therapeutic effects of chamomile are beneficial to patients will require research and generation of scientific evidence.

    • There is a need for continued efforts that focuses on pre-clinical studies with chamomile involving animal models of various diseases.

    • This may then be consequently validated in clinical trials that will help in developing chamomile as a promising therapeutic agent.

    • Without such evidence, it will remain unclear whether these untested and unproven medical treatments are truly beneficial.

    • It is advisable that the discriminate and proper use of chamomile preparations could be safe and provide therapeutic benefits however the indiscriminate or improper use can be unsafe and harmful.

    A recent review article (2016) entitled “A systematic review study of therapeutic effects of Matricaria recuitta chamomile (chamomile)” published in Electronic Physician concluded:

    • In this study, the therapeutic effects of chamomile were reviewed in detail.

    • The therapeutic effects of Matricaria recuitta chamomile also were reviewed in detail.

    • The findings of this study indicated that this plant is commonly used for its antioxidant, antimicrobial, antidepression, anti-inflammatory, antidiarrheal and angiogenesis activity, anticarcinogenic, hepatoprotective, and antidiabetic effects.

    • Besides, it is beneficial for knee osteoarthritis, ulcerative colitis, premenstrual syndrome, and gastrointestinal disorders.

    • Antimicrobial activity (antiparasitic, antibacterial, antiviral properties) was reported.

    • Many studies confirmed the antioxidative effects of this plant;

    • finally, more complementary studies in different therapeutic effects of this herb in clinical trial studies may be appropriate for future studies.

    Fine’s Sleep Aid Pectin Gummies 

    Chamomile Extract is one of the active ingredients in Fine’s Sleep Aid Pectin Gummies for kids. This product is a balanced safe and effective supplement of natural ingredients designed to induce and maintain a natural, enjoyable, refreshing and a high quality sleep for kids. This product may also:

    • Have calming and relaxing effects

    • Improve anxiety and stress

    • Prevent type 2 diabetes due to inadequate duration of sleep during childhood

    • Boost the immune system and provide protection against various kinds of infections

    • Improve gastrointestinal disorders including stomach irritation, intestinal colic and bloating

    • Improve allergic reactions

    • Improve migraine headaches

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